association of variable number of tandem repeats in endothelial nitric oxide synthase gene with coronary artery disease
نویسندگان
چکیده
endo-derived nitric oxide (no) is synthesized from l-arginine by endothelium nitric oxide synthase (enos). since reduced no synthesis has been implicated in the development of coronary atherosclerosis; we hypothesized that polymorphisms of nos gene might be associated with increased susceptibility to this disorder and coronary artery disease (cad). we studied the 27 base pair tandem repeat polymorphism in intron4 of the endothelial nitric oxide synthase (enos) gene in 141 unrelated cad patients with positive coronary angiograms in shahid rajaee heart hospital and 159 age matched control subjects without a history of symptomatic cad. the study protocol was approved by the iran university of medical sciences ethics committee. the enos gene intron4a/b vntr polymorphism was analyzed by polymerase chain reaction. the plasma lipids levels and other risk factors were also determined. the genotype frequencies for enos4b/b, enos4a/b and enos4a/a were 68.8, 29.1 and 2.1% in cad subjects, and 81, 18.4 and 0.6 % in control subjects, respectively. the genotype frequencies differed significantly between the two groups (χ²= 6.38 p= 0.041). the frequency of the allele was 16.7% in cad subjects and 9.8% in control subjects and was significantly higher in the patients (χ²= 6.18 p= 0.013, odds ratio=1.84). plasma lipids, except hdl-c were also remarkablely increased in cad group.
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Association between T-786C polymorphism of endothelial nitric oxide synthase gene and level of the vessel dilation factor in patients with coronary artery disease
Various polymorphisms on endothelial nitric oxide synthase (eNOs) gene cause reduced production of NO, the endothelial relaxing factor, and may accelerate the process of atherosclerosis. The study designed to investigate the frequency of T-786C polymorphism of the eNOs gene in patients suffering from coronary artery disease (CAD) in north-west of Iran. One hundred twenty subjects including 60 p...
متن کاملRetraction Note: Association between T-786C polymorphism of endothelial nitric oxide synthase gene and level of the vessel dilation factor in patients with coronary artery disease
متن کامل
Retraction note: Association between T-786C polymorphism of endothelial nitric oxide synthase gene and level of the vessel dilation factor in patients with coronary artery disease
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متن کاملEndothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with coronary artery disease in Iran.
BACKGROUND & OBJECTIVES Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7. Since reduced NO synthesis has been implicated in the development of coronary atherosclerosis; polymorphisms of NOS gene might be associated with increased susceptibility to this disorder and coronary artery disease (CAD). We ...
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عنوان ژورنال:
iranian journal of public healthجلد ۳۵، شماره ۴، صفحات ۱۵-۲۱
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